Dot 3, 4, and 5.1 are all glycol based, and can be mixed. Your Spyder uses dot 4, so using dot 3 would be a downgrade in the boiling point, and isn't a good idea. Fluids marked "dot3/dot4" are acceptable. Just don't use dot 5, which is silicone based, extra bad idea.
Regarding "synthetic"--glycol based (3, 4, and 5.1) are all synthetic. It's just a marketing gimmick to make people think it's better.